Lake Santa Fe is designated by the State of Florida as an Outstanding Florida Water which, according to the Florida Department of Environmental Protection, means it is “worthy of special protection because of its natural attributes.” The lake covers approximately 5,856 acres and, along with the 7,046-acre Santa Fe Swamp at the north end of the lake, is considered the headwaters of the Santa Fe River, the largest tributary of the mighty Suwannee River.